Man's Best Friend is an American science fiction/horror film directed by John Lafia. It stars Lance Henriksen and Ally Sheedy and was produced by New Line Cinema. It was released theatrically in the United States on November 19th, 1993. In the spirit of Cujo, Man's Best Friend adds a new chapter to the predatory animal subgenre and involves a Tibetan Mastiff that has has been genetically augmented to be the perfect killing machine. Television personality Lori Tanner (Sheedy) adopts the animal, unaware of it's sinister origins, but soon learns the truth when her new pet begins creating terror, killing mailmen and chasing cats up trees. Lance Henriksen plays the obsessed scientist Doctor Jarret, who is charged with tracking down his missing experiment and stopping him before he kills again.
Actress Ally Sheedy will always be remembered as the hat and coat-wearing misfit Allison Reynolds from The Breakfast Club, but she has appeared in many other works as well, such as 1990's Fear, where she played a psyhic, the 1994 television movie The Haunting of Seacliff Inn where she had the starring role of Susan Enright, and 1997's Buried Alive II, where she played Laura Riskin.