A demon of hunger known as Mnemoth has been released in New York City and begins infecting various people. Those infected by Mnemoth's influence become ravenously hungry. But the more they eat, the hungrier they become. Henry Wambach starves to death despite the fact that he eats copious amounts of food.
In London, John Constantine returns to his flat to find one of his old band mates from Mucous Membrane, Gary Lester in his apartment. Gary is sitting in his bathtub covered in bugs. John sprays him down with aerosol and tries to calm Gary down. Gary tells John, that he had tried to contain the essence of Mnemoth after a botched exorcism upon a young Sudanese boy. He mailed the bottled demon to the address of one of John's old girlfriends in New York (believing that John was still staying there).
First, John travels to the Sudan to consult with a medicine man as to the nature of Mnemoth. He then takes Gary and travels to New York to make contact with the Voodoo crime lord, Papa Midnite. He tells Midnite that it would be in his best interest to help him against Mnemoth. He asks Midnite to watch over Gary Lester.
John then goes to the apartment of his old girlfriend, Emma. The demon bottle is not there. He finds Emma's ghost who walks and chats with him for a while. John realizes that Mnemoth has been released and he follows trails of swarming insects to an old church. He faces off with Mnemoth in his full fury. John races out of the church, unable to stop Mnemoth.
This issue features a fictitious magazine article written by Satchmo Hawkins entitled, "Faces on the Street". The column appears as a feature in XS Magazine and is partially printed on the inside front cover of this issue.
First apperance of Papa Midnite - a Haitian occultist. Papa Midnite becomes a recurring supporting character for the remainder of the series and the title character of his own five-issue limited series in 2005. He chronologically appeared last in flashback in Hellblazer #72. He appears next in Hellblazer #2.
First appearance of Gary Lester - a drug addicted occultist. Gary Lester makes a chronlogically earlier appearance in a flashback in Hellblazer #11, which precedes the flashback sequences from this issue. He appears next in Hellblazer #2.
First appearance of Ali - a new shop clerk. He appears next in Hellblazer #4.
First and only appearance to date of the Dinkan shaman; appears in flashback only.
First and only appearance of Eddie - one of Mnemoth's victims; dies in this issue.
First and only appearance to date of Gino - a hot dog vendor.
First and only appearance of Henry Wambach - a post office employee; dies in this issue.
First and only appearance to date of Kenny - a Londoner.
First and only appearance to date of Marty - a diner.
First appearance of Mighty Mouse - John's neighbor.
First appearance of Mrs. McGuire - John's landlady.